The Titans nearly pulled off a stunning upset as double-digit underdogs last week, narrowly losing to the Kansas City Chiefs 20-17 in overtime. One of the model's strongest Week 10 NFL picks is that the Titans (-2.5) cover the spread at home against the Broncos almost 60% of the time. Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. Which teams should you target in your NFL survivor picks and NFL office pool picks? All of the Week 10 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now. Savvy bettors could jump on the Chargers with their Week 10 NFL picks, especially since Los Angeles is a perfect 4-0 against the spread on the road. They include the Packers (+5) against the Cowboys and the Chargers (+7) visiting the 49ers. That is the highest percentage through nine weeks since 1999, and there are eight such dogs this week, according to the NFL odds and NFL spreads from Caesars Sportsbook. NFL underdogs of four-plus points have fared well versus the spread entering the Week 10 NFL schedule, covering in 65% of their games.

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